A slicer for Prusa, Creality, Voron, Klipper and Anycubic printers
Unlayered Slicer ships OrcaSlicer's printer profiles. If OrcaSlicer supports your printer, so does Unlayered Slicer, with non-planar slicing, wave overhangs and fewer multicolor swaps on top.
Prusa MK4, MK4S, Core One, XL and Mini
PrusaSlicer is tuned closely to Prusa hardware and is the sensible default. Unlayered Slicer is the PrusaSlicer alternative for wave overhangs and fewer multicolor swaps, using OrcaSlicer's Prusa profiles, including the MK4 and Core One.
Creality Ender 3, K1 and K2
On an Ender 3, OrcaSlicer's flow and pressure advance tests (included) fix many extrusion problems behind bad prints. On the K1 and K2, wave overhangs and fewer filament swaps matter more. Creality Print remains the option with Creality's own integration.
Voron and other Klipper printers
Most Klipper users already run OrcaSlicer, so switching only adds things: non-planar layers along the load path, wave overhangs, fewer swaps, and tools aimed at speed and strength. Vorons' small, low ducts leave more nozzle clearance, so non-planar layers can curve more steeply.
Anycubic, Elegoo, Sovol, Qidi and others
If OrcaSlicer has a profile, so does Unlayered Slicer; otherwise build one as you would in OrcaSlicer. Bambu Lab owners: see the Bambu Lab page, since wireless printing isn't supported yet.